The interaction between DAP1 and autophagy in the context of human carcinogenesis

Autophagy is an evolutionarily-conserved catabolic process which furthers cell survival, especially in times of nutritional stress. Whilst being by itself a pro-survival mechanism, it has many areas of overlap with apoptosis. Autophagic cell death is recognised as a subset of programmed cell death,...

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Published inAnticancer research Vol. 34; no. 1; p. 1
Main Authors Wazir, Umar, Khanzada, Zubair S, Jiang, Wen G, Sharma, Anup K, Kasem, Abdul, Mokbel, Kefah
Format Journal Article
LanguageEnglish
Published Greece 01.01.2014
Subjects
Apoptosis Regulatory Proteins - metabolism
Autophagy
Carcinogenesis - metabolism
Carcinogenesis - pathology
Humans
carcinogenesis
macroautophagy
review
oncogenesis
apoptosis
breast cancer
Autophagy
death-associated protein 1
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Summary:Autophagy is an evolutionarily-conserved catabolic process which furthers cell survival, especially in times of nutritional stress. Whilst being by itself a pro-survival mechanism, it has many areas of overlap with apoptosis. Autophagic cell death is recognised as a subset of programmed cell death, with features more typical of autophagy rather than classical apoptosis. The mechanisms preventing autophagy from unravelling into autophagic cell death are still the subject of much controversy. We discuss the current understanding of these mechanisms, including recent research regarding the role of death-associated protein-1 in autophagy and apoptosis.
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ISSN:1791-7530
1791-7530