Menopause and Mood: The Role of Estrogen in Midlife Depression and Beyond
Depression is a disabling condition that often leads to significant burden. Women are more vulnerable to depression during reproductive-related "windows of vulnerability" such as the menopause transition and early postmenopausal years. This heightened vulnerability can be attributed, at le...
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| Published in | The Psychiatric clinics of North America Vol. 46; no. 3; p. 463 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.09.2023
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Depression is a disabling condition that often leads to significant burden. Women are more vulnerable to depression during reproductive-related "windows of vulnerability" such as the menopause transition and early postmenopausal years. This heightened vulnerability can be attributed, at least in part, to the neuromodulatory effects of estrogen on mood and cognition and the exposure to rapid fluctuations of estradiol levels during midlife years. The management of midlife depression can be challenging due to the presence and severity of other complaints such as vasomotor symptoms and sleep disturbances. Psychopharmacologic, behavioral, and hormonal interventions should be part of the treatment armamentarium. |
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| AbstractList | Depression is a disabling condition that often leads to significant burden. Women are more vulnerable to depression during reproductive-related "windows of vulnerability" such as the menopause transition and early postmenopausal years. This heightened vulnerability can be attributed, at least in part, to the neuromodulatory effects of estrogen on mood and cognition and the exposure to rapid fluctuations of estradiol levels during midlife years. The management of midlife depression can be challenging due to the presence and severity of other complaints such as vasomotor symptoms and sleep disturbances. Psychopharmacologic, behavioral, and hormonal interventions should be part of the treatment armamentarium. |
| Author | Soares, Claudio N |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37500244$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2023 Elsevier Inc. All rights reserved. |
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| Keywords | Depression Perimenopause Treatments Menopause Estrogen |
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| Title | Menopause and Mood: The Role of Estrogen in Midlife Depression and Beyond |
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