High vs Low PEEP in Patients With ARDS Exhibiting Intense Inspiratory Effort During Assisted Ventilation: A Randomized Crossover Trial

• Published in: Chest Vol. 165; no. 6; p. 1392
• Main Authors: Bello, Giuseppe, Giammatteo, Valentina, Bisanti, Alessandra, Delle Cese, Luca, Rosà, Tommaso, Menga, Luca S, Montini, Luca, Michi, Teresa, Spinazzola, Giorgia, De Pascale, Gennaro, Pennisi, Mariano Alberto, Ribeiro De Santis Santiago, Roberta, Berra, Lorenzo, Antonelli, Massimo, Grieco, Domenico Luca
• Format: Journal Article
• Language: English
• Published: United States 01.06.2024
• Subjects: inspiratory effort; artificial ventilation; self-inflicted lung injury; PEEP; respiratory mechanics; ventilator-induced lung injury; ARDS

Positive end-expiratory pressure (PEEP) can potentially modulate inspiratory effort (ΔPes), which is the major determinant of self-inflicted lung injury. Does high PEEP reduce ΔPes in patients with moderate-to-severe ARDS on assisted ventilation? Sixteen patients with Pao /Fio  ≤ 200 mm Hg and ΔPes ...