High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis

• Published in: Clinical and experimental rheumatology Vol. 37; no. 6; p. 983
• Main Authors: Ascone, Giuliana, Di Ceglie, Irene, van den Bosch, Martijn H J, Kruisbergen, Nik N L, Walgreen, Birgitte, Sloetjes, Annet W, Lindhout, Ernst, Joosten, Leo A B, van de Loo, Fons A J, Koenders, Marije I, van der Kraan, Peter M, Blom, Arjen B, van Lent, Peter L E M
• Format: Journal Article
• Language: English
• Published: Italy 01.11.2019
• Subjects: Animals; Arthritis, Experimental - immunology; Arthritis, Experimental - metabolism; Arthritis, Experimental - pathology; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Cholesterol, LDL - blood; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, IgG

In this study, we used hypercholesterolaemic apolipoprotein E-deficient (Apoe-/-) mice to investigate LDL/oxLDL effect on synovial inflammation and cartilage destruction during antigen-induced arthritis (AIA). Further, as macrophage FcγRs are crucial to immune complex-mediated AIA, we investigated i...