An efficient total synthesis of leukotriene B4

• Published in: Organic & biomolecular chemistry Vol. 13; no. 19; pp. 5412 - 5417
• Main Authors: Primdahl, Karoline Gangestad, Tungen, Jorn Eivind, Aursnes, Marius, Hansen, Trond Vidar, Vik, Anders
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 21.05.2015
• Subjects: Aldehydes - chemical synthesis; Aldehydes - chemistry; Alkynes - chemical synthesis; Alkynes - chemistry; Chemistry; Chemistry, Organic; Leukotriene B4 - biosynthesis; Leukotriene B4 - chemical synthesis; Leukotriene B4 - chemistry; Physical Sciences; Science & Technology; LIPID MEDIATOR; POLYMORPHONUCLEAR LEUKOCYTES; CONJUGATE REDUCTION; PROPARGYLIC ALCOHOLS; ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS; OMEGA-OXIDATION; ARACHIDONIC-ACID; PROTECTIN D1; REDUCTIVE ELIMINATION; HYDRIDE

Lipid mediators have attracted great interest from scientists within the chemical, medicinal, and pharmaceutical research community. One such example is leukotriene B-4 which has been the subject of many pharmacological studies. Herein, we report a convergent and stereoselective synthesis of this po...