Involvement of the p75(NTR) signaling pathway in persistent synaptic suppression coupled with synapse elimination following repeated long-term depression induction

• Published in: Journal of neuroscience research Vol. 88; no. 16; pp. 3433 - 3446
• Main Authors: Egashira, Yoshihiro, Tanaka, Tsunehiro, Soni, Priyanka, Sakuragi, Shigeo, Tominaga-Yoshino, Keiko, Ogura, Akihiko
• Format: Journal Article
• Language: English
• Published: United States 01.12.2010
• Subjects: Animals; Apoptosis - physiology; Brain-Derived Neurotrophic Factor - metabolism; Hippocampus - metabolism; In Vitro Techniques; Long-Term Synaptic Depression - physiology; Nerve Growth Factors - metabolism; Neural Inhibition - physiology; Neurons - metabolism; Protein Precursors - metabolism; Rats; Rats, Wistar; Receptor, Nerve Growth Factor - metabolism; Receptors, Metabotropic Glutamate - agonists; Signal Transduction - physiology

Synaptic plasticity, especially structural plasticity, is thought to be a basis for long-lasting memory. We previously reported that, in rat hippocampus slice cultures, repeated induction of long-term depression (LTD) by application of a metabotropic glutamate receptor (mGluR) agonist led to slowly...