Splicing of the Survival Motor Neuron genes and implications for treatment of SMA
Proximal spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of the survival motor neuron (SMN) protein. The reduced SMN levels are due to loss of the survival motor neuron-1 (SMN1) gene. Humans carry a nearly identical SMN2 gene that generates a truncated protein, due to a...
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Published in | Frontiers in bioscience (Landmark. Print) Vol. 15; no. 3; p. 1191 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Singapore
01.06.2010
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Subjects | |
Online Access | Get more information |
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