Effects of therapeutic doses of Pregabalin on QTc interval in conscious rabbits

• Published in: European review for medical and pharmacological sciences Vol. 12; no. 4; p. 223
• Main Authors: Alp, R, Citil, M, Uzun, M, Alp, S, Topcu, B, Uzlu, E, Erdogan, H M
• Format: Journal Article
• Language: English
• Published: Italy 01.07.2008
• Subjects: Administration, Oral; Animals; Anticonvulsants - administration & dosage; Anticonvulsants - adverse effects; Dose-Response Relationship, Drug; Electrocardiography; Female; gamma-Aminobutyric Acid - administration & dosage; gamma-Aminobutyric Acid - adverse effects; gamma-Aminobutyric Acid - analogs & derivatives; Heart Rate - drug effects; Long QT Syndrome - chemically induced; Male; Pregabalin; Rabbits; Time Factors

Pregabalin (PRG) is a new antiepileptic drug that has been used as supportive therapy for partial seizures in patients. Although many neuro-psychiatric and non-cardiac drugs are known to prolong ventricular repolarization as manifested by QTc prolongation on ECG of which provokes torsades de pointes...