Inefficient processing of mRNA for the membrane form of IgE is a genetic mechanism to limit recruitment of IgE-secreting cells

• Published in: European journal of immunology Vol. 36; no. 7; pp. 1917 - 1925
• Main Authors: Karnowski, Alexander, Achatz-Straussberger, Gertrude, Klockenbusch, Cordula, Achatz, Gernot, Lamers, Marinus C
• Format: Journal Article
• Language: English
• Published: Germany 01.07.2006
• Subjects: Animals; Antibody-Producing Cells - cytology; Antibody-Producing Cells - immunology; Antibody-Producing Cells - metabolism; Cell Line, Tumor; Cell Movement - genetics; Cell Movement - immunology; Cells, Cultured; Humans; Immunoglobulin E - biosynthesis; Immunoglobulin E - genetics; Immunoglobulin E - metabolism; Mice; Mice, Knockout; Receptors, IgE - deficiency; Receptors, IgE - genetics; RNA Processing, Post-Transcriptional - immunology; RNA, Messenger - metabolism

Immunoglobulin E (IgE) is the key effector element in allergic diseases ranging from innocuous hay fever to life-threatening anaphylactic shock. Compared to other Ig classes, IgE serum levels are very low. In its membrane-bound form (mIgE), IgE behaves as a classical antigen receptor on B lymphocyte...