Effects of atenolol and propranolol on platelet aggregation in moderate essential hypertension: randomized crossover trial
To compare the effects of a selective beta-blocker atenolol and a nonselective beta-blocker propranolol on platelet aggregation. Twenty successive outpatients with moderate essential hypertension (6 women and 14 men, mean age-/+standard deviation 42.6-/+8.5 years) were randomized to either propranol...
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Published in | Croatian medical journal Vol. 46; no. 2; pp. 219 - 224 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Croatia
01.04.2005
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Abstract | To compare the effects of a selective beta-blocker atenolol and a nonselective beta-blocker propranolol on platelet aggregation.
Twenty successive outpatients with moderate essential hypertension (6 women and 14 men, mean age-/+standard deviation 42.6-/+8.5 years) were randomized to either propranolol (40 mg three times a day) or atenolol (100 mg once a day) for the first two weeks, followed by a one-day washout period, and then a two-week administration of the alternative drug. Along with standard examinations and tests, circulating platelet aggregates were measured.
There were no significant differences in creatinine, blood glucose, potassium, total cholesterol, hemoglobin, red blood cells (RBC), or platelets in three periods: baseline, atenolol, and propranolol period. Significant and comparable reductions in systolic and diastolic arterial pressure, body weight, heart rate, and HDL-cholesterol were recorded in both patient groups. The LDL-cholesterol concentration increased significantly in propranolol compared with both baseline and atenolol period. Serum triglycerides increased significantly with both medications. The number of circulating platelet aggregates decreased significantly with propranolol (0.99-/+0.19) in comparison with both atenolol (1.41-/+0.70; P=0.004, Wilcoxon matched pairs test) and baseline (1.59-/+0.94; P=0.002, Wilcoxon matched pairs test).
Propranolol inhibits platelet aggregation more than atenolol and may have a favorable effect on the management of hypertension especially in patients with increased cardiovascular risk. |
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AbstractList | To compare the effects of a selective beta-blocker atenolol and a nonselective beta-blocker propranolol on platelet aggregation.
Twenty successive outpatients with moderate essential hypertension (6 women and 14 men, mean age-/+standard deviation 42.6-/+8.5 years) were randomized to either propranolol (40 mg three times a day) or atenolol (100 mg once a day) for the first two weeks, followed by a one-day washout period, and then a two-week administration of the alternative drug. Along with standard examinations and tests, circulating platelet aggregates were measured.
There were no significant differences in creatinine, blood glucose, potassium, total cholesterol, hemoglobin, red blood cells (RBC), or platelets in three periods: baseline, atenolol, and propranolol period. Significant and comparable reductions in systolic and diastolic arterial pressure, body weight, heart rate, and HDL-cholesterol were recorded in both patient groups. The LDL-cholesterol concentration increased significantly in propranolol compared with both baseline and atenolol period. Serum triglycerides increased significantly with both medications. The number of circulating platelet aggregates decreased significantly with propranolol (0.99-/+0.19) in comparison with both atenolol (1.41-/+0.70; P=0.004, Wilcoxon matched pairs test) and baseline (1.59-/+0.94; P=0.002, Wilcoxon matched pairs test).
Propranolol inhibits platelet aggregation more than atenolol and may have a favorable effect on the management of hypertension especially in patients with increased cardiovascular risk. AIMTo compare the effects of a selective beta-blocker atenolol and a nonselective beta-blocker propranolol on platelet aggregation.METHODSTwenty successive outpatients with moderate essential hypertension (6 women and 14 men, mean age-/+standard deviation 42.6-/+8.5 years) were randomized to either propranolol (40 mg three times a day) or atenolol (100 mg once a day) for the first two weeks, followed by a one-day washout period, and then a two-week administration of the alternative drug. Along with standard examinations and tests, circulating platelet aggregates were measured.RESULTSThere were no significant differences in creatinine, blood glucose, potassium, total cholesterol, hemoglobin, red blood cells (RBC), or platelets in three periods: baseline, atenolol, and propranolol period. Significant and comparable reductions in systolic and diastolic arterial pressure, body weight, heart rate, and HDL-cholesterol were recorded in both patient groups. The LDL-cholesterol concentration increased significantly in propranolol compared with both baseline and atenolol period. Serum triglycerides increased significantly with both medications. The number of circulating platelet aggregates decreased significantly with propranolol (0.99-/+0.19) in comparison with both atenolol (1.41-/+0.70; P=0.004, Wilcoxon matched pairs test) and baseline (1.59-/+0.94; P=0.002, Wilcoxon matched pairs test).CONCLUSIONPropranolol inhibits platelet aggregation more than atenolol and may have a favorable effect on the management of hypertension especially in patients with increased cardiovascular risk. |
Author | Punda, Ante Bagatin, Jugoslav Polić, Stojan Rumboldt, Zvonko Lukin, Ajvor Marković, Vinko |
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Snippet | To compare the effects of a selective beta-blocker atenolol and a nonselective beta-blocker propranolol on platelet aggregation.
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SubjectTerms | Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Adult Atenolol - pharmacology Atenolol - therapeutic use Cross-Over Studies Female Humans Hypertension - drug therapy Hypertension - physiopathology Male Platelet Aggregation - drug effects Propranolol - pharmacology Propranolol - therapeutic use Prospective Studies |
Title | Effects of atenolol and propranolol on platelet aggregation in moderate essential hypertension: randomized crossover trial |
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