Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease

• Published in: Brain pathology (Zurich, Switzerland) Vol. 18; no. 2; p. 225
• Main Authors: Zuccato, Chiara, Marullo, Manuela, Conforti, Paola, MacDonald, Marcy E, Tartari, Marzia, Cattaneo, Elena
• Format: Journal Article
• Language: English
• Published: Switzerland 01.04.2008
• Subjects: Aged; Brain - metabolism; Brain - pathology; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Enzyme-Linked Immunosorbent Assay - methods; Female; Humans; Huntington Disease - metabolism; Huntington Disease - pathology; Male; Middle Aged; Postmortem Changes; Receptor, Nerve Growth Factor - genetics; Receptor, Nerve Growth Factor - metabolism; Receptor, trkB - genetics; Receptor, trkB - metabolism; Severity of Illness Index

One cardinal feature of Huntington's disease (HD) is the degeneration of striatal neurons, whose survival greatly depends on the binding of cortical brain-derived neurotrophic factor (BDNF) with high-affinity (TrkB) and low-affinity neurotrophin receptors [p75 pan-neurotrophin receptor (p75(NTR...