p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis

• Published in: Cancer treatment reviews Vol. 35; no. 3; pp. 210 - 220
• Main Authors: Tsoumpou, I, Arbyn, M, Kyrgiou, M, Wentzensen, N, Koliopoulos, G, Martin-Hirsch, P, Malamou-Mitsi, V, Paraskevaidis, E
• Format: Journal Article
• Language: English
• Published: Netherlands 01.05.2009
• Subjects: Alphapapillomavirus; Biomarkers - analysis; Biomarkers, Tumor - analysis; Biopsy; Cervical Intraepithelial Neoplasia - chemistry; Cervical Intraepithelial Neoplasia - diagnosis; Cervix Uteri - chemistry; Cervix Uteri - pathology; Cervix Uteri - virology; Colposcopy; Cyclin-Dependent Kinase Inhibitor p16 - analysis; Cytological Techniques - utilization; Female; Histological Techniques - utilization; Humans; Immunohistochemistry - utilization; Neoplasm Proteins - analysis; Papillomavirus Infections - diagnosis; Papillomavirus Infections - metabolism; Predictive Value of Tests; Prospective Studies; Research Design; Retrospective Studies; Uterine Cervical Dysplasia - metabolism; Uterine Cervical Dysplasia - virology; Uterine Cervical Neoplasms - chemistry; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - virology; Uterine Cervicitis - diagnosis; Uterine Cervicitis - metabolism; Vaginal Smears

P16(INK4a) is a biomarker for transforming HPV infections that could act as an adjunct to current cytological and histological assessment of cervical smears and biopsies, allowing the identification of those women with ambiguous results that require referral to colposcopy and potentially treatment....