Lactate, not glucose, up-regulates mitochondrial oxygen consumption both in sham and lateral fluid percussed rat brains

• Published in: Neurosurgery Vol. 59; no. 5; p. 1122
• Main Authors: Levasseur, Joseph E, Alessandri, Beat, Reinert, Michael, Clausen, Tobias, Zhou, Zhengwen, Altememi, Nabil, Bullock, M Ross
• Format: Journal Article
• Language: English
• Published: United States 01.11.2006
• Subjects: Animals; Brain - drug effects; Brain - physiopathology; Brain Injuries - physiopathology; Cell Respiration - drug effects; Dose-Response Relationship, Drug; Glucose - administration & dosage; Lactic Acid - administration & dosage; Male; Mitochondria - drug effects; Mitochondria - metabolism; Oxygen - metabolism; Oxygen Consumption - drug effects; Rats; Rats, Sprague-Dawley; Up-Regulation - drug effects

Failure of energy metabolism after traumatic brain injury may be a major factor limiting outcome. Although glucose is the primary metabolic substrate in the healthy brain, the well documented surge in tissue lactate after traumatic brain injury suggests that lactate may provide an energy need that c...