Multimodal safety assessment of measles‐mumps‐rubella vaccination after pediatric liver transplantation

• Published in: American journal of transplantation Vol. 19; no. 3; pp. 844 - 854
• Main Authors: Pittet, Laure F., Verolet, Charlotte M., McLin, Valérie A., Wildhaber, Barbara E., Rodriguez, Maria, Cherpillod, Pascal, Kaiser, Laurent, Siegrist, Claire‐Anne, Posfay‐Barbe, Klara M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.03.2019
• Subjects: Adolescent; Antibodies, Viral - immunology; Cell number; Child; Child, Preschool; clinical research/practice; clinical trial; Female; Follow-Up Studies; Humans; Immunization; Immunocompromised Host - drug effects; Immunocompromised Host - immunology; Immunoglobulin G; Immunosuppression; Immunosuppression Therapy; Infant; Infant, Newborn; infection and infectious agents—viral; infectious disease; Liver; Liver transplantation; Liver Transplantation - methods; liver transplantation/hepatology; Liver transplants; Male; Measles; Measles - immunology; Measles - prevention & control; Measles virus - immunology; Measles-Mumps-Rubella Vaccine - administration & dosage; Measles-Mumps-Rubella Vaccine - immunology; Mumps; Mumps - immunology; Mumps - prevention & control; Mumps virus - immunology; Patient Safety - statistics & numerical data; Pediatrics; Prognosis; Prospective Studies; Risk Assessment - methods; Rubella; Rubella - immunology; Rubella - prevention & control; Rubella virus - immunology; Transplants & implants; Vaccination; vaccine; Vaccines; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - immunology; clinical trial; vaccine; infectious disease; clinical research/practice; pediatrics; infection and infectious agents-viral; liver transplantation/hepatology

Live‐attenuated vaccines are currently contraindicated in solid‐organ transplant recipients. However, the risk of vaccine‐preventable infections is lifelong, and can be particularly severe after transplantation. In this prospective interventional national cohort study, 44 pediatric liver transplant...