Artesunate restores mitochondrial fusion‐fission dynamics and alleviates neuronal injury in Alzheimer's disease models

• Published in: Journal of neurochemistry Vol. 162; no. 3; pp. 290 - 304
• Main Authors: Qin, Yi‐Ren, Ma, Chi‐Qian, Jiang, Jian‐Hua, Wang, Da‐Peng, Zhang, Quan‐Quan, Liu, Mei‐Rong, Zhao, Hong‐Ru, Fang, Qi, Liu, Yang
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2022
• Subjects: Alzheimer's disease; Amyloid precursor protein; Apoptosis; Artemisinin; Artesunate; Cellular manufacture; Cytokines; Dementia disorders; Fission; Fusion protein; Inflammation; Microglia; Microglial cells; Mitochondria; mitochondrial dynamics; mitophagy; Neurodegeneration; Neurodegenerative diseases; neuroinflammation; Neurological diseases; Oxidative stress; Phenotypes; Presenilin; Presenilin 1; Proteins; Reactive oxygen species; mitophagy; artesunate; neuroinflammation; Alzheimer's disease; oxidative stress; mitochondrial dynamics

Alzheimer's disease (AD) remains a leading cause of dementia and no therapy that reverses underlying neurodegeneration is available. Recent studies suggest the protective role of artemisinin, an antimalarial drug, in neurological disorders. In this study, we investigated the therapeutic potenti...