Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion

• Published in: Cell and tissue research Vol. 322; no. 2; pp. 207 - 215
• Main Authors: Salehi, A, Flodgren, E, Nilsson, N E, Jimenez-Feltstrom, J, Miyazaki, J, Owman, C, Olde, B
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2005
• Subjects: 2-bromo palmitate; Animals; Biologi; Biological Sciences; Cell Biology; Cell Line; Cellbiologi; Fatty Acids - metabolism; Female; free fatty acid; GPR40; Humans; Hypoglycemic Agents - metabolism; insulin; Insulin - metabolism; Insulin Secretion; Islets of Langerhans - cytology; Islets of Langerhans - metabolism; Linoleic Acid - metabolism; Mice; mouse (NMRI); Natural Sciences; Naturvetenskap; Oligonucleotides, Antisense - metabolism; Palmitates - metabolism; pancreatic islet; Phosphatidylinositols - metabolism; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism

Free fatty acids (FFA) have generally been proposed to regulate pancreatic insulin release by an intracellular mechanism involving inhibition of CPT-1. The recently de-orphanized G-protein coupled receptor, FFA(1)R/GPR40, has been shown to be essential for fatty-acid-stimulated insulin release in MI...