Séquelles neurologiques secondaires à une intoxication aiguë au lithium

Objectif: Analyse de la documentation sur les séquelles neurologiques permanentes secondaires à une intoxication aiguë au lithium. Méthode: Soixante-six articles en langue française et anglaise ont été passés en revue de 1968 à 1997 en utilisant Medline. Résultats: Cinquante-neuf cas ont été examiné...

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Published inCanadian journal of psychiatry Vol. 44; no. 7; pp. 671 - 679
Main Authors Roy, Mario, Stip, Emmanuel, Black, Deborah N, Lew, Vivianne, Langlois, Robert
Format Journal Article
LanguageFrench
Published Los Angeles, CA SAGE Publications 01.09.1999
Canadian Psychiatric Association
SAGE PUBLICATIONS, INC
Subjects
Bipolar disorder
Drugs
Mental illness
Pharmacologie. Traitements medicamenteux
Physiological aspects
Sciences biologiques et medicales
Sciences medicales
Therapy
Toxicité des médicaments et traitement des toxicités dues aux médicaments
Toxicité: système nerveux et muscle
toxicity
antipsychotics
lithium
ataxia
cerebellum
neurological side effects
Association médicamenteuse
Normothymique
Symptomatologie
Lithium
Trouble humeur
Traitement
Homme
Toxicité
Système nerveux pathologie
Chimiothérapie
Article synthèse
Psychotrope
Trouble bipolaire
Neuroleptique
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Abstract Objectif: Analyse de la documentation sur les séquelles neurologiques permanentes secondaires à une intoxication aiguë au lithium. Méthode: Soixante-six articles en langue française et anglaise ont été passés en revue de 1968 à 1997 en utilisant Medline. Résultats: Cinquante-neuf cas ont été examinés dans la documentation et classifiés selon trois registres: le premier concerne les cas d'intoxication au lithium sans neuroleptique ayant entraîné un syndrome cérébelleux; le deuxième regroupe les cas où le lithium a été associé à un neuroleptique; et le troisième groupe présente des cas de séquelles neurologiques diverses, qu 'il y ait eu ou non association avec un neuroleptique. Conclusions: Le lithium présente une toxicité intrinsèque pour le système nerveux central et un tropisme particulier pour le cervelet. L'association avec des neuroleptiques semble augmenter sa toxicité ainsi que certains facteurs associés dont les états infectieux et la correction rapide de la lithémie. Nous discutons des mécanismes physiopathologiques actuellement invoqués pour expliquer la neurotoxicité du lithium.
AbstractList Objectif: Analyse de la documentation sur les séquelles neurologiques permanentes secondaires à une intoxication aiguë au lithium. Méthode: Soixante-six articles en langue française et anglaise ont été passés en revue de 1968 à 1997 en utilisant Medline. Résultats: Cinquante-neuf cas ont été examinés dans la documentation et classifiés selon trois registres: le premier concerne les cas d'intoxication au lithium sans neuroleptique ayant entraîné un syndrome cérébelleux; le deuxième regroupe les cas où le lithium a été associé à un neuroleptique; et le troisième groupe présente des cas de séquelles neurologiques diverses, qu 'il y ait eu ou non association avec un neuroleptique. Conclusions: Le lithium présente une toxicité intrinsèque pour le système nerveux central et un tropisme particulier pour le cervelet. L'association avec des neuroleptiques semble augmenter sa toxicité ainsi que certains facteurs associés dont les états infectieux et la correction rapide de la lithémie. Nous discutons des mécanismes physiopathologiques actuellement invoqués pour expliquer la neurotoxicité du lithium.
Author Lew, Vivianne
Langlois, Robert
Stip, Emmanuel
Black, Deborah N
Roy, Mario
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Issue 7
Keywords toxicity
antipsychotics
lithium
ataxia
cerebellum
neurological side effects
Association médicamenteuse
Normothymique
Symptomatologie
Lithium
Trouble humeur
Traitement
Homme
Toxicité
Système nerveux pathologie
Chimiothérapie
Article synthèse
Psychotrope
Trouble bipolaire
Neuroleptique
Language French
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Snippet Objectif: Analyse de la documentation sur les séquelles neurologiques permanentes secondaires à une intoxication aiguë au lithium. Méthode: Soixante-six...
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SubjectTerms Bipolar disorder
Drugs
Mental illness
Pharmacologie. Traitements medicamenteux
Physiological aspects
Sciences biologiques et medicales
Sciences medicales
Therapy
Toxicité des médicaments et traitement des toxicités dues aux médicaments
Toxicité: système nerveux et muscle
Title Séquelles neurologiques secondaires à une intoxication aiguë au lithium
URI https://journals.sagepub.com/doi/full/10.1177/070674379904400704
https://www.proquest.com/docview/222857446
Volume 44
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