Novel trypanosomatid small nucleolar RNAs that guide methylation: their genome organization, expression and potential use to direct specific methylation on target RNA molecules

• Published in: The Israel Medical Association journal Vol. 2 Suppl; pp. 58 - 62
• Main Authors: Xu, Y X, Liu, L, Michaeli, S
• Format: Journal Article
• Language: English
• Published: Israel 01.07.2000
• Subjects: Animals; Animals, Genetically Modified; Chromosome Mapping; Cloning, Molecular; Gene Expression Regulation; Genetic Engineering; Genome, Protozoan; Methylation; Mitochondria - metabolism; Ribose - metabolism; RNA; RNA Precursors - genetics; RNA Splicing - genetics; RNA, Protozoan - genetics; RNA, Ribosomal, 18S - genetics; RNA, Ribosomal, 5.8S - genetics; RNA, Small Nucleolar - genetics; Transcription, Genetic; Trypanosomatina - genetics

Trypanosomatids are the causative agent of several major parasitic diseases including African trypanosomiasis, American trypanosomiasis, and leishmaniasis. These parasites possess unique RNA-processing mechanisms including trans-splicing of pre-mRNA and RNA editing of mitochondrial transcripts. In t...