VCaP, a cell-based model system of human prostate cancer

• Published in: In vivo (Athens) Vol. 15; no. 2; p. 163
• Main Authors: Korenchuk, S, Lehr, J E, MClean, L, Lee, Y G, Whitney, S, Vessella, R, Lin, D L, Pienta, K J
• Format: Journal Article
• Language: English
• Published: Greece 01.03.2001
• Subjects: Acid Phosphatase; Animals; Cell Culture Techniques - methods; Cell Division; Epithelial Cells - chemistry; Epithelial Cells - cytology; Female; Humans; Karyotyping; Keratins - analysis; Male; Mice; Mice, SCID; Middle Aged; Prostate-Specific Antigen - analysis; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Protein Tyrosine Phosphatases - analysis; Receptors, Androgen - genetics; RNA, Messenger - analysis; Spinal Neoplasms - genetics; Spinal Neoplasms - secondary; Tumor Cells, Cultured - cytology

We report the isolation and characterization of a novel prostate cancer cell line derived from a vertebral metastatic lesion, Vertebral-Cancer of the Prostate (VCaP). Prostate cancer tissue was harvested at autopsy from a metastatic lesion to a lumbar vertebral body of a patient with hormone refract...