Multiple response elements and differential p53 binding control Perp expression during apoptosis

• Published in: Molecular cancer research Vol. 1; no. 14; pp. 1048 - 1057
• Main Authors: Reczek, Elizabeth E, Flores, Elsa R, Tsay, Alice S, Attardi, Laura D, Jacks, Tyler
• Format: Journal Article
• Language: English
• Published: United States 01.12.2003
• Subjects: Animals; Apoptosis; Cell Cycle; Cells, Cultured; Chromatin - genetics; Chromatin - immunology; Chromatin - metabolism; Fibroblasts; Gene Expression Regulation; Membrane Proteins - metabolism; Mice; Promoter Regions, Genetic - genetics; Protein Binding; Response Elements; Transcriptional Activation; Tumor Suppressor Protein p53 - metabolism

The p53 tumor suppressor gene responds to cellular stress by activating either cell cycle arrest or apoptosis. A growing number of target genes involved in each of these pathways have been identified. However, the mechanism by which the apoptosis versus arrest decision is made remains to be elucidat...