Immune inhibitory effects of renal cell carcinoma extract on lectin and alloantigen-induced peripheral blood and tumor infiltrating lymphocyte blastogenesis

• Published in: Urologic oncology Vol. 21; no. 1; p. 27
• Main Authors: Shabtai, M, Ye, H, Kono, K, Takayam, T, Terashima, K, Tsukuda, K, Frischer, Z, Waltzer, W C, Malinowski, K
• Format: Journal Article
• Language: English
• Published: United States 01.01.2003
• Subjects: Adenocarcinoma, Clear Cell - chemistry; Adenocarcinoma, Clear Cell - immunology; Aged; Biological Factors - isolation & purification; Biological Factors - pharmacology; Blood Cells - drug effects; Carcinoma, Renal Cell - chemistry; Carcinoma, Renal Cell - immunology; Carcinoma, Transitional Cell - chemistry; Carcinoma, Transitional Cell - immunology; Cells, Cultured - drug effects; Concanavalin A - pharmacology; Female; Humans; Immune Tolerance; Isoantigens - immunology; Kidney - chemistry; Kidney Neoplasms - chemistry; Kidney Neoplasms - immunology; Lymphocyte Activation - drug effects; Lymphocytes, Tumor-Infiltrating - drug effects; Lymphocytes, Tumor-Infiltrating - immunology; Male; Middle Aged; Organ Specificity; Phytohemagglutinins - pharmacology; Pokeweed Mitogens - pharmacology; Tissue Extracts - isolation & purification; Tissue Extracts - pharmacology

The presence of tumor infiltrating lymphocytes (TIL) has been attributed to the host cell mediated immune response against the evolving malignancy. However, due to specific evasive and escape mechanisms, the immune competent cells are rendered ineffective. One such mechanism may be the production of...