Bacteriophages provide regulatory signals in mitogen-induced murine splenocyte proliferation

• Published in: Cellular & molecular biology letters Vol. 8; no. 3; pp. 699 - 711
• Main Authors: Zimecki, Michał, Weber-Dabrowska, Beata, Łusiak-Szelachowska, Marzanna, Mulczyk, Marian, Boratyński, Janusz, Poźniak, Gryzelda, Syper, Danuta, Górski, Andrzej
• Format: Journal Article
• Language: English
• Published: England 2003
• Subjects: Animals; Bacteriophages - isolation & purification; Bacteriophages - metabolism; Cell Division; Cells, Cultured; Colorimetry; Concanavalin A - pharmacology; Dose-Response Relationship, Drug; Female; Interleukin-6 - biosynthesis; Lipopolysaccharides - pharmacology; Macrophages, Peritoneal - drug effects; Male; Mice; Mice, Inbred CBA; Mitogens - pharmacology; Rats; Rats, Wistar; Signal Transduction; Spleen - cytology; Spleen - drug effects; Staphylococcus aureus - growth & development

The aim of this investigation was to reveal the regulatory properties of bacteriophage preparations in a model of mitogen-induced splenocyte proliferation in mice. We showed that sepharose 4B-purified preparations of the Staphylococcus aureus phage A20/R exhibited costimulatory activity in splenocyt...