Thymidylate synthase inhibitors
Thymidylate synthase (TS) is a critical enzyme for DNA replication and cell growth because it is the only de novo source of thymine nucleotide precursors for DNA synthesis. TS is the primary target of 5-fluorouracil (5-FU), which has been used for cancer treatment for more than 40 years. However, di...
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Published in | Seminars in oncology Vol. 26; no. 6; p. 621 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
01.12.1999
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Subjects | |
Online Access | Get more information |
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