The soluble IL-6 receptors: serum levels and biological function

• Published in: Cellular and molecular biology (Noisy-le-Grand, France) Vol. 47; no. 4; p. 583
• Main Author: Montero-Julian, F A
• Format: Journal Article
• Language: English
• Published: France 01.06.2001
• Subjects: Amino Acid Sequence; Animals; Antigens, CD - physiology; Cytokine Receptor gp130; Humans; Interleukin-6 - physiology; Macromolecular Substances; Membrane Glycoproteins - physiology; Molecular Sequence Data; Receptors, Interleukin-6 - blood; Receptors, Interleukin-6 - chemistry; Receptors, Interleukin-6 - genetics; Receptors, Interleukin-6 - physiology; Signal Transduction; Solubility

IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. IL-6 binds first to a low-affinity (10(-9) M) subunit, a 80 kDa glycoprotein also called gp80 or IL-6R alpha. The IL-6/IL-6R alpha complex recruits the signal-transducing b sub...