Effect of imidapril on heterogeneity of slow component of delayed rectifying K+ current in rabbit left ventricular hypertrophic myocytes

• Published in: Acta pharmacologica Sinica Vol. 24; no. 7; p. 681
• Main Authors: Li, Yang, Lu, Zai-Ying, Xiao, Jian-Men, Ma, Jie, Niu, Hui-Yan, Liu, Nian, Ruan, Yan-Fei
• Format: Journal Article
• Language: English
• Published: United States 01.07.2003
• Subjects: Action Potentials - drug effects; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Animals; Female; Hypertrophy, Left Ventricular - pathology; Imidazoles - pharmacology; Imidazolidines; Male; Myocytes, Cardiac - drug effects; Potassium Channels - metabolism; Potassium Channels, Voltage-Gated; Rabbits

To investigate the transmural heterogeneous change of slow component of delayed rectifying potassium current in rabbit left ventricular hypertrophic myocytes and the effect of long-term treatment with imidapril (Imi). Rabbits were divided into hypertrophy group (left ventricular hypertrophy induced...