Pharmacokinetics of ofloxacin in severe chronic renal failure

• Published in: Clinical therapeutics Vol. 11; no. 2; p. 210
• Main Authors: Bandai, H, Tsubakihara, Y, Yamato, E, Yokoyama, K, Okada, N, Nakanishi, I, Iida, N
• Format: Journal Article
• Language: English
• Published: United States 01.03.1989
• Subjects: Creatinine - blood; Half-Life; Humans; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - therapy; Ofloxacin - pharmacokinetics; Renal Dialysis

The pharmacokinetics of ofloxacin were studied in patients with severe renal impairment. In five healthy subjects and nine patients with chronic renal failure (CRF) (creatinine clearance [CCR] less than 20 ml/min) receiving 100 mg of ofloxacin orally in the fasted state, the serum concentration was...