Expression of the c-erbB-2 gene product (p185) at different stages of neoplastic progression in the colon

• Published in: Oncogene Vol. 4; no. 10; p. 1233
• Main Authors: D'Emilia, J, Bulovas, K, D'Ercole, K, Wolf, B, Steele, Jr, G, Summerhayes, I C
• Format: Journal Article
• Language: English
• Published: England 01.10.1989
• Subjects: Antibody Specificity; Colon - analysis; Colonic Neoplasms - analysis; Colonic Polyps - analysis; DNA, Neoplasm - analysis; Gene Amplification; Gene Expression; Humans; Neoplasm Staging; Precancerous Conditions - analysis; Proto-Oncogene Proteins - analysis; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - immunology; Receptor, ErbB-2

The c-erbB-2 gene has been found amplified in a number of human adenocarcinomas leading to elevated levels of expression of the p185 protein product. Increased expression of this putative growth factor receptor has been reported to occur by molecular mechanism other than gene amplification and for t...