ELISA & lepromin skin tests in household contacts of leprosy patients

A total of 438 household contacts of leprosy patients and 228 non-contacts were studied for anti-PGL-I antibodies and cell mediated immune response to Mycobacterium leprae using ELISA and lepromin tests. The contacts showed relatively higher positivity to ELISA (29.4%) and lepromin (70.5%) as compar...

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Published inIndian journal of medical research (New Delhi, India : 1994) Vol. 91; pp. 431 - 436
Main Authors Dhandayuthapani, S, Anandan, D, Bhatia, V N
Format Journal Article
LanguageEnglish
Published India 01.11.1990
Subjects
Adolescent
Adult
Antibodies, Bacterial - blood
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunity, Cellular
Immunoglobulin M - analysis
Lepromin - immunology
Leprosy - immunology
Male
Middle Aged
Mycobacterium leprae - immunology
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Summary:A total of 438 household contacts of leprosy patients and 228 non-contacts were studied for anti-PGL-I antibodies and cell mediated immune response to Mycobacterium leprae using ELISA and lepromin tests. The contacts showed relatively higher positivity to ELISA (29.4%) and lepromin (70.5%) as compared to non-contacts who showed 9.6 and 57 per cent positivity. In contacts as well as non-contacts the seropositivity was not found to be influenced by age and sex. However, seropositivity was higher (39.7%) in the contacts of patients with multibacillary leprosy as compared to contacts (27.7%) of patients with paucibacillary leprosy.
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ISSN:0971-5916