Ornithine decarboxylase--a predictor for tumor chemosensitivity

• Published in: Cellular and molecular biology (Noisy-le-Grand, France) Vol. 40; no. 7; p. 957
• Main Authors: Bachrach, U, Shayovitz, A, Marom, Y, Ramu, A, Ramu, N
• Format: Journal Article
• Language: English
• Published: France 01.11.1994
• Subjects: Animals; Biomarkers; Cell Division - drug effects; Doxorubicin - pharmacology; Drug Resistance; Humans; Leukemia P388 - drug therapy; Leukemia P388 - enzymology; Leukemia P388 - pathology; Methotrexate - pharmacology; Mice; Ornithine Decarboxylase - metabolism; Tumor Cells, Cultured - drug effects; Tumor Cells, Cultured - enzymology; Tumor Cells, Cultured - pathology; Vinblastine - pharmacology

The activity of ornithine decarboxylase (ODC) was determined in P388 murine leukemia cells treated with adriamycin (ADR) and methotrexate (MTX). Some of the cell lines were resistant to ADR, MTX or their combinations. A similar pattern was found between the cytotoxicity and the suppression of ODC ac...