Ornithine decarboxylase--a predictor for tumor chemosensitivity
The activity of ornithine decarboxylase (ODC) was determined in P388 murine leukemia cells treated with adriamycin (ADR) and methotrexate (MTX). Some of the cell lines were resistant to ADR, MTX or their combinations. A similar pattern was found between the cytotoxicity and the suppression of ODC ac...
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Published in | Cellular and molecular biology (Noisy-le-Grand, France) Vol. 40; no. 7; p. 957 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
France
01.11.1994
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Abstract | The activity of ornithine decarboxylase (ODC) was determined in P388 murine leukemia cells treated with adriamycin (ADR) and methotrexate (MTX). Some of the cell lines were resistant to ADR, MTX or their combinations. A similar pattern was found between the cytotoxicity and the suppression of ODC activity in these cell lines in terms of drug concentrations. In a cell line resistant to one drug, a relatively high concentration of that drug was required to inhibit ODC activity. This effect was independent of the sensitivity of the cells to the other drug. A similar correlation between arrest of growth and the inhibition in the induction of ODC was also observed in human epithelial carcinoma cells. In this case too, the growth of multidrug resistant cells was not affected by vinblastine, neither was the induction of ODC. On the other hand, both the growth and the induction of ODC were inhibited by vinblastine in drug-sensitive cells. These findings suggest that ODC measurements might be used for predicting the chemosensitivity of tumor cells. |
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AbstractList | The activity of ornithine decarboxylase (ODC) was determined in P388 murine leukemia cells treated with adriamycin (ADR) and methotrexate (MTX). Some of the cell lines were resistant to ADR, MTX or their combinations. A similar pattern was found between the cytotoxicity and the suppression of ODC activity in these cell lines in terms of drug concentrations. In a cell line resistant to one drug, a relatively high concentration of that drug was required to inhibit ODC activity. This effect was independent of the sensitivity of the cells to the other drug. A similar correlation between arrest of growth and the inhibition in the induction of ODC was also observed in human epithelial carcinoma cells. In this case too, the growth of multidrug resistant cells was not affected by vinblastine, neither was the induction of ODC. On the other hand, both the growth and the induction of ODC were inhibited by vinblastine in drug-sensitive cells. These findings suggest that ODC measurements might be used for predicting the chemosensitivity of tumor cells. |
Author | Ramu, N Bachrach, U Shayovitz, A Marom, Y Ramu, A |
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Snippet | The activity of ornithine decarboxylase (ODC) was determined in P388 murine leukemia cells treated with adriamycin (ADR) and methotrexate (MTX). Some of the... |
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SubjectTerms | Animals Biomarkers Cell Division - drug effects Doxorubicin - pharmacology Drug Resistance Humans Leukemia P388 - drug therapy Leukemia P388 - enzymology Leukemia P388 - pathology Methotrexate - pharmacology Mice Ornithine Decarboxylase - metabolism Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - enzymology Tumor Cells, Cultured - pathology Vinblastine - pharmacology |
Title | Ornithine decarboxylase--a predictor for tumor chemosensitivity |
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