Neuroendocrine neoplasms arising in inflammatory bowel disease: a report of 14 cases

• Published in: Modern pathology Vol. 11; no. 6; p. 537
• Main Authors: Sigel, J E, Goldblum, J R
• Format: Journal Article
• Language: English
• Published: United States 01.06.1998
• Subjects: Adult; Aged; Chromogranin A; Chromogranins - metabolism; Female; Humans; Immunohistochemistry; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - pathology; Male; Microscopy, Electron; Middle Aged; Neuroendocrine Tumors - complications; Neuroendocrine Tumors - metabolism; Neuroendocrine Tumors - pathology; Neuroendocrine Tumors - ultrastructure; Phosphopyruvate Hydratase - metabolism; Synaptophysin - metabolism

Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), is a premalignant condition, because these patients are at increased risk of adenocarcinoma. Neuroendocrine neoplasms (NENs) have rarely been described in this setting. We evaluated 14 cases of NEN arising in a setting of IBD. A...