Angiogenin is regulated in vivo as an acute phase protein

• Published in: Biochemical and biophysical research communications Vol. 242; no. 3; pp. 480 - 483
• Main Authors: Olson, K A, Verselis, S J, Fett, J W
• Format: Journal Article
• Language: English
• Published: United States 26.01.1998
• Subjects: Acute-Phase Proteins - metabolism; Animals; Blotting, Northern; Gene Expression Regulation - genetics; Inflammation - chemically induced; Liver - metabolism; Mice; Protein Biosynthesis; Proteins - metabolism; Radioimmunoassay; Ribonuclease, Pancreatic; RNA, Messenger - analysis; RNA, Messenger - metabolism; Serum Amyloid A Protein - metabolism; Thioglycolates - pharmacology; Time Factors

Angiogenin (Ang), a potent mediator of neovascularization, is secreted by and is critical for the growth of human tumor cells in experimental animals. However, control mechanisms that regulate its expression under normal physiological conditions have not been described. We have determined previously...