Quantitative and qualitative differences in growth, invasion and lung colonization of an anaplastic and a papillary human thyroid cancer cell line in vitro and in vivo

• Published in: Clinical & experimental metastasis Vol. 14; no. 5; p. 440
• Main Authors: Boghaert, E R, Ain, K, Taylor, K, Greenberg, V L, Fowler, C, Zimmer, S G
• Format: Journal Article
• Language: English
• Published: Netherlands 01.10.1996
• Subjects: Animals; Basement Membrane - pathology; Carcinoma - pathology; Carcinoma, Papillary - pathology; Cell Division; Gelatinases - metabolism; Humans; Lung Neoplasms - secondary; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Thyroid Neoplasms - pathology; Tumor Cells, Cultured

Invasion and metastasis remain major reasons for failure of anti-cancer therapy. Cell lines derived from human carcinomas are frequently used to investigate the molecular mechanisms that underlie invasion and metastasis. Unfortunately many of these cell lines do not retain the malignant characterist...