Analytical methods for therapeutic drug monitoring

The availability of new immunoassay and chromatographic methods has led to the revolution in therapeutic drug monitoring. The immunochemical and chromatographic methods both meet the analytical requirements of sensitivity, precision, and accuracy needed for most TDM applications. The technique chose...

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Bibliographic Details
Published inThe American journal of medical technology Vol. 49; no. 8; p. 551
Main Authors Boguslaski, R C, Burd, J F
Format Journal Article
LanguageEnglish
Published United States 01.08.1983
Subjects
Chromatography, Gas - methods
Chromatography, Liquid - methods
Drug Therapy
Enzyme-Linked Immunosorbent Assay
Fluorescence
Fluorescence Polarization
Humans
Immunoassay - methods
Monitoring, Physiologic - methods
Nephelometry and Turbidimetry
Pharmaceutical Preparations - analysis
Radioimmunoassay - methods
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Summary:The availability of new immunoassay and chromatographic methods has led to the revolution in therapeutic drug monitoring. The immunochemical and chromatographic methods both meet the analytical requirements of sensitivity, precision, and accuracy needed for most TDM applications. The technique chosen for any laboratory will depend upon numerous factors such as the availability of personnel and equipment, the time required to perform the assay, the speed with which the clinician needs the results, and the cost and medical benefit to the patient. It is reasonable to assume that the rapid development of new equipment and methodologies will continue to keep therapeutic drug monitoring one of the most interesting and fastest growing areas in clinical medicine.
ISSN:0002-9335