Action of staphylococcal alpha-toxin on membranes: some recent advances

Recent developments in the area of Staphylococcal alpha-toxin studies are presented which modify the concepts previously held with respect to both biological and physical properties of alpha-toxin. New data concerning the nature of the binding site for alpha-toxin on rabbit erythrocyte membranes and...

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Bibliographic Details
Published inMolecular and cellular biochemistry Vol. 23; no. 3; p. 143
Main Author Harshman, S
Format Journal Article
LanguageEnglish
Published Netherlands 09.02.1979
Subjects
Animals
Bacterial Toxins - metabolism
Bacterial Toxins - pharmacology
Binding Sites
Erythrocyte Membrane - drug effects
Erythrocyte Membrane - metabolism
Erythrocytes - drug effects
Hemolysis - drug effects
Humans
In Vitro Techniques
Iodine Radioisotopes
Mice
Models, Biological
Myelin Sheath - drug effects
Neurotoxins - pharmacology
Rabbits
Staphylococcus
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Summary:Recent developments in the area of Staphylococcal alpha-toxin studies are presented which modify the concepts previously held with respect to both biological and physical properties of alpha-toxin. New data concerning the nature of the binding site for alpha-toxin on rabbit erythrocyte membranes and a model to explain the various observed complexes of alpha-toxin and membrane receptor are discussed. Finally, evidence suggesting that Staphylococcal alpha-toxin is a potent demyelinating agent is presented.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF00219453