Potential fungicidal and bactericidal agents. Synthesis of certain 4-(2-amino-1,3,4-thiadiazol-5-yl)quinolines

• Published in: Pharmazie Vol. 34; no. 9; p. 537
• Main Authors: El-Dine, S A, El-Khawass, S M
• Format: Journal Article
• Language: English
• Published: Germany 1979
• Subjects: Anti-Bacterial Agents; Anti-Infective Agents - chemical synthesis; Antifungal Agents - chemical synthesis; Bacteria - drug effects; Fungi - drug effects; Quinolines - chemical synthesis; Quinolines - pharmacology

The synthesis of some new 4-[2-alkyl (aryl or aralkyl) amino-1,3,4-thiadiazol-5-yl]-2-substituted quinolines is described. IR, UV, NMR and MS data of representative examples are discussed. Most of the compounds prepared showed a reasonable antifungal and antimicrobial activity.