AAZTA‐Like Ligands Bearing Phenolate Arms as Efficient Chelators for 68Ga Labelling in vitro and in vivo

• Published in: Chemistry : a European journal Vol. 29; no. 21
• Main Authors: Martinelli, Jonathan, Zapelli, Leonardo Maria, Boccalon, Mariangela, Vágner, Adrienn, Nagy, Gábor, Fekete, Anikó, Szikra, Dezső, Trencsényi, György, Baranyai, Zsolt, Tei, Lorenzo
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 13.04.2023; Wiley Subscription Services, Inc
• Subjects: Acetic acid; Chelating agents; Chemistry; Chemistry, Multidisciplinary; gallium; imaging agents; Labeling; ligand design; Ligands; PET; pH effects; Physical Sciences; Radioactive tracers; Radiochemistry; radiopharmaceuticals; Room temperature; Science & Technology; Stability; Tumors; αvβ3 integrin targeting; ACTIVATION; CONSTANTS; alpha(v)beta integrin targeting; STABILITY; gallium; imaging agents; RADIOTRACERS; radiopharmaceuticals; RADIOCHEMISTRY; ligand design; HBED-CC; DOTA; PET; GALLIUM(III) COMPLEXES

The introduction of a phenolate pendant arm in place of an acetate on AAZTA‐ and DATA‐like ligands resulted in hepta‐ and hexadentate chelators able to form Ga(III) complexes with thermodynamic stability and kinetic inertness higher than that of other Ga(III) complexes based on the parent 6‐amino‐6‐...