PSMA-GCK01: A Generator-Based 99mTc/188Re Theranostic Ligand for the Prostate-Specific Membrane Antigen

• Published in: The Journal of nuclear medicine (1978) Vol. 64; no. 7; pp. 1069 - 1075
• Main Authors: Cardinale, Jens, Giesel, Frederik L, Wensky, Christina, Rathke, Hendrik G, Haberkorn, Uwe, Kratochwil, Clemens
• Format: Journal Article
• Language: English
• Published: New York Society of Nuclear Medicine 01.07.2023
• Subjects: Antigens; Basic Science Investigation; Labeling; Labels; Ligands; Lutetium isotopes; Medical imaging; Membranes; Precision medicine; Prostate; Prostate cancer; Radioisotopes; Radiolabelling; Tumors

Prostate-specific membrane antigen (PSMA) theranostics have been introduced with 68Ga and 177Lu, the most used radionuclides. However, 188Re is a well-known generator-based therapeutic nuclide that completes a theranostic tandem with 99mTc and may offer an interesting alternative to the currently us...