Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 314; no. 3; pp. L493 - L504
• Main Authors: Ghavami, Saeid, Yeganeh, Behzad, Zeki, Amir A, Shojaei, Shahla, Kenyon, Nicholas J, Ott, Sean, Samali, Afshin, Patterson, John, Alizadeh, Javad, Moghadam, Adel Rezaei, Dixon, Ian M C, Unruh, Helmut, Knight, Darryl A, Post, Martin, Klonisch, Thomas, Halayko, Andrew J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.03.2018

Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited treatment options. Autophagy and the unfolded protein response (UPR), fundamental processes induced by cell stress, are dysregulated in lung fibroblasts and epithelial cells from humans with IPF. Human prima...