Effect of 1‐ and 2‐Month High‐Dose Alpha‐Linolenic Acid Treatment on 13C‐Labeled Alpha‐Linolenic Acid Incorporation and Conversion in Healthy Subjects

• Published in: Molecular nutrition & food research Vol. 62; no. 20
• Main Authors: Pignitter, Marc, Lindenmeier, Michael, Andersen, Gaby, Herrfurth, Cornelia, Beermann, Christopher, Schmitt, Joachim J., Feussner, Ivo, Fulda, Martin, Somoza, Veronika
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.10.2018; John Wiley and Sons Inc
• Subjects: acid treatment; ALA conversion; alpha-linolenic acid; carbon; Carbon 13; compartment model; Conversion; Diet; Dietary intake; Erythrocytes; Fish oils; food intake; Homology; isotope labeling; LDL; Linolenic acid; Linseed oil; Low density lipoprotein; Oils & fats; omega‐3 fatty acids; Phospholipids; Reduction; stable isotopes
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.201800271

Scope The study aims at identifying 1) the most sensitive compartment among plasma phospholipids, erythrocytes, and LDL for studying alpha‐linolenic acid (ALA) conversion, and 2) whether ALA incorporation and conversion is saturable after administration of 13C‐labeled ALA‐rich linseed oil (LO). The...