Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients

• Published in: Oncology reports Vol. 31; no. 4; pp. 1683 - 1690
• Main Authors: AKIYAMA, YASUTO, KOMIYAMA, MASARU, MIYATA, HARUO, YAGOTO, MIKA, ASHIZAWA, TADASHI, IIZUKA, AKIRA, OSHITA, CHIE, KUME, AKIKO, NOGAMI, MASAHIRO, ITO, ICHIRO, WATANABE, REIKO, SUGINO, TAKASHI, MITSUYA, KOICHI, HAYASHI, NAKAMASA, NAKASU, YOKO, YAMAGUCHI, KEN
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.04.2014; Spandidos Publications UK Ltd
• Subjects: Antigens; Antigens, Neoplasm - analysis; Antigens, Neoplasm - biosynthesis; Biomarkers, Tumor - analysis; Brain cancer; Brain Neoplasms - metabolism; Brain Neoplasms - mortality; Brain Neoplasms - pathology; cancer-testis antigen; Cell Line, Tumor; Female; Gene expression; Glioma; Glioma - metabolism; Glioma - mortality; Glioma - pathology; glioma-related gene expression database; high-grade glioma; Humans; Immunoglobulins; Immunohistochemistry; Kaplan-Meier Estimate; Laboratories; Male; Medical prognosis; Middle Aged; Neoplasm Grading; Penicillin; quantitative PCR; Real-Time Polymerase Chain Reaction; Studies; Survival analysis; Tumors; United States > US

Glioblastoma multiforme (GBM) is one of the most malignant and aggressive tumors, and has a very poor prognosis with a mean survival time of <2 years, despite intensive treatment using chemo-radiation. Therefore, novel therapeutic approaches including immunotherapy have been developed against GBM...