A novel variant of growth hormone (GH) insufficiency following low dose cranial irradiation

• Published in: Clinical endocrinology (Oxford) Vol. 36; no. 1; p. 59
• Main Authors: Crowne, E C, Moore, C, Wallace, W H, Ogilvy-Stuart, A L, Addison, G M, Morris-Jones, P H, Shalet, S M
• Format: Journal Article
• Language: English
• Published: England 01.01.1992
• Subjects: Adolescent; Child; Child, Preschool; Cranial Irradiation - adverse effects; Growth Hormone - blood; Growth Hormone - deficiency; Growth Hormone - metabolism; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - radiotherapy; Puberty - blood; Secretory Rate - physiology

We aimed to investigate the effect of low dose (1800 cGy) prophylactic cranial irradiation on physiological growth hormone secretion. We performed an analysis of 24-hour serum GH profiles using 20-minute sampling. Forty-four children were studied, of whom 21 were long-term survivors of acute lymphob...