The biochemical mechanisms of the stimulating action of estradiol on the growth of mammary tumours

• Published in: Experimental and clinical endocrinology Vol. 88; no. 3; p. 293
• Main Authors: Morozova, T M, Mitina, R L, Nagibneva, I N, Ozhogina, Z B, Salganik, R I
• Format: Journal Article
• Language: English
• Published: Germany 01.12.1986
• Subjects: Animals; Cyclic AMP - metabolism; Estradiol - metabolism; Female; Mammary Neoplasms, Experimental - metabolism; Mice; Neoplasms, Hormone-Dependent - metabolism; Ovariectomy; Protein Kinases - metabolism; Rats; Rats, Inbred Strains; Receptors, Estradiol - analysis; Receptors, Estradiol - metabolism; Receptors, Estrogen - metabolism

The mechanisms of stimulating effect of estradiol on the growth of hormone-dependent mammary tumours in experimental animals were studied. Estradiol receptors were detected in plasmatic membranes of estradiol-dependent tumour cells. Estradiol-independence of tumours was found to be a result of the i...