Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application

• Published in: Quantitative imaging in medicine and surgery Vol. 1; no. 1; pp. 35 - 40
• Main Author: Wang, Yi-Xiang J
• Format: Journal Article
• Language: English
• Published: China AME Publishing Company 01.12.2011
• Subjects: Review; Neoplasm; iron oxide; MRI; SPIO; Liver; Hepatocellular carcinoma; Contrast media

Superparamagnetic iron oxide (SPIO) MR contrast agents are composed of nano-sized iron oxide crystals coated with dextran or carboxydextran. Two SPIO agents are clinically approved, namely: ferumoxides (Feridex in the USA, Endorem in Europe) with a particle size of 120 to 180 nm, and ferucarbotran (...