Osteopontin in Bone Metabolism and Bone Diseases

• Published in: Medical science monitor Vol. 26; pp. e919159 - e919159-9
• Main Authors: Si, Jinyan, Wang, Chaowei, Zhang, Denghui, Wang, Bo, Zhou, Yi
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 30.01.2020
• Subjects: Animals; Bone and Bones - metabolism; Bone and Bones - pathology; Bone Development; Bone Diseases - metabolism; Calcinosis - pathology; Humans; Organ Size; Osteopontin - metabolism; Review
• ISSN: 1643-3750; 1234-1010; 1643-3750
• DOI: 10.12659/MSM.919159

Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many biological activities. Studies have shown that OPN plays a role in bone metabolism and homeostasis. OPN not only is an important factor in neuron-mediated and endocrine-regulated bone mass, but also is involved in biological activities such as proliferation, migration, and adhesion of several bone-related cells, including bone marrow mesenchymal stem cells, hematopoietic stem cells, osteoclasts, and osteoblasts. OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as osteoporosis, rheumatoid arthritis, and osteosarcoma. As expected, the functions of OPN in the bone have become a research hotspot. In this article, we try to decipher the mechanism of OPN-regulated bone metabolism and bone diseases.