Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells - Selmin, Ornella I; Fang, Changming; Lyon, Adam M; Doetschman, Tom C; Thompson, Patricia A; Martinez, Jesse D; Smith, Jeffrey W; Lance, Peter M; Romagnolo, Donato F (The Journal of nutrition, 2016)
Keywords: Adenocarcinoma - genetics; Adenomatous Polyposis Coli - genetics; Animals; Bile Acids and Salts - metabolism; Colon - metabolism; Colonic Neoplasms - genetics; Cyclooxygenase 2 - metabolism; DNA Methylation; Gene Expression; Gene Silencing; Genes, APC; HCT116 Cells; HT29 Cells; Humans; Mice, Inbred C57BL; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc - metabolism; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; CpG methylation; adenomatous polyposis coli; farnesoid X receptor; inflammation; colon cancer; bile acid metabolism; deoxycholic acid; epigenetics