Effect of Ponesimod, a Selective S1P1 Receptor Modulator, on the QT Interval in Healthy Individuals - Hoch, Matthias; Darpo, Borje; Brossard, Patrick; Zhou, Meijian; Stoltz, Randall; Dingemanse, Jasper (Basic & clinical pharmacology & toxicology, 2015)
Keywords: Action Potentials; Adolescent; Adult; Confidence intervals; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug therapy; Electrocardiography; Female; Fluoroquinolones - adverse effects; Healthy Volunteers; Heart Conduction System - drug effects; Heart Conduction System - physiopathology; Heart Rate - drug effects; Humans; Long QT Syndrome - chemically induced; Long QT Syndrome - physiopathology; Male; Middle Aged; Receptors, Lysosphingolipid - drug effects; Receptors, Lysosphingolipid - metabolism; Risk Assessment; Thiazoles - administration & dosage; Thiazoles - adverse effects; Thiazoles - pharmacokinetics; Time Factors; Young Adult