Flavonoid-induced gastroprotection in rats : Role of blood flow and leukocyte adherence

• Published in: Digestion Vol. 58; no. 2; pp. 147 - 154
• Main Authors: BLANK, M. A, EMS, B. L, O'BRIEN, L. M, WEISSHAAR, P. S, ARES, J. J, ABEL, P. W, MCCAFFERTY, D.-M, WALLACE, J. L
• Format: Journal Article
• Language: English
• Published: Freiburg Karger 01.03.1997; Basel S. Karger AG; Paris
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Biological and medical sciences; Cell Adhesion - drug effects; Disease Models, Animal; Flavonoids - pharmacology; Gastric Mucosa - blood supply; Gastrointestinal Agents - pharmacology; General pharmacology; In Vitro Techniques; Indomethacin - administration & dosage; Indomethacin - pharmacology; Laser-Doppler Flowmetry; Leukocytes - metabolism; Male; Medical sciences; Mesenteric Arteries - physiology; Muscle Relaxation - physiology; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Rats; Rats, Inbred Strains; Regional Blood Flow - physiology; Stomach Diseases - chemically induced; Stomach Ulcer - prevention & control; Stomach; Iatrogenic; Rat; Digestive system; Leukocyte; Toxicity; Rodentia; Pharmacovigilance; Experimental study; Adhesion; Flavonoid; Blood flow; Non steroidal antiinflammatory agent; Toxicology; Vertebrata; Chemotherapy; Relation; Mammalia; Cytoprotector; Animal; Complication; Biological effect; Lesion

To elucidate the mechanisms of flavonoid-induced protection against nonsteroidal anti-inflammatory drug (indomethacin)-induced acute gastric damage, the effects of 5-methoxyflavone and 5-methoxyflavanone on the gastric vasculature were compared both in vivo (using laser Doppler flowmetry in anesthet...