Cell death and DNA damage via ROS mechanisms after applied antibiotics and antioxidants doses in prostate hyperplasia primary cell cultures

• Published in: Medicine (Baltimore) Vol. 103; no. 37; p. e39450
• Main Authors: Matei, Elena, Ionescu, Anita Cristina, Enciu, Manuela, Popovici, Violeta, Mitroi, Anca Florentina, Aschie, Mariana, Deacu, Mariana, Băltățescu, Gabriela Isabela, Nicolau, Antonela-Anca, Roșu, Mihai Cătălin, Cristian, Miruna, Dobrin, Nicolae, Ștefanov, Constanța, Pundiche Butcaru, Mihaela, Cozaru, Georgeta Camelia
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 13.09.2024
• Subjects: Anti-Bacterial Agents - pharmacology; Antioxidants - pharmacology; Apoptosis - drug effects; Ascorbic Acid - pharmacology; Autophagy - drug effects; Cell Cycle Checkpoints - drug effects; Cell Death - drug effects; Chloramphenicol - pharmacology; DNA Damage - drug effects; Erythromycin - pharmacology; Humans; Male; Observational Study; Oxidative Stress - drug effects; Primary Cell Culture; Prostatic Hyperplasia - drug therapy; Prostatic Hyperplasia - metabolism; Prostatic Hyperplasia - pathology; Reactive Oxygen Species - metabolism; Vitamin E - pharmacology

Tumor heterogeneity results in aggressive cancer phenotypes with acquired resistance. However, combining chemical treatment with adjuvant therapies that cause cellular structure and function perturbations may diminish the ability of cancer cells to resist at chemical treatment and lead to a less agg...