MicroRNA‐125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2

• Published in: Hepatology (Baltimore, Md.) Vol. 52; no. 5; pp. 1731 - 1740
• Main Authors: Liang, Linhui, Wong, Chun‐Ming, Ying, Qiao, Fan, Dorothy Ngo‐Yin, Huang, Shenglin, Ding, Jie, Yao, Jian, Yan, Mingxia, Li, Jinjun, Yao, Ming, Ng, Irene Oi‐Lin, He, Xianghuo
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2010; Wolters Kluwer Health, Inc
• Subjects: Cell cycle; Cell Cycle - drug effects; Cell Division - drug effects; Cell growth; Cell Movement - drug effects; Colony-Forming Units Assay; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - drug effects; Down-Regulation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, Reporter; Hepatology; Humans; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - pathology; MicroRNAs - genetics; MicroRNAs - pharmacology; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - drug effects; RNA, Messenger - genetics; RNA-Binding Proteins; Transfection

MicroRNAs (miRNAs) are small, noncoding RNAs that can act as oncogenes or tumor suppressors in human cancer. Our previous study showed that miR‐125b was a prognostic indicator for patients with hepatocellular carcinoma (HCC), but its functions and exact mechanisms in hepatic carcinogenesis are still...